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Phenotypes Associated with This Genotype
Genotype
MGI:5659910
Allelic
Composition
Krastm4Tyj/Kras+
Tg(CAG-HPV16E6E7,-luc)#Mspi/0
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(CAG-HPV16E6E7,-luc)#Mspi mutation (0 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tamoxifen treated mice develop oral tumors; tumors grow faster than in single conditional Kras mutants
• oral tumors of tamoxifen treated mice are papillomas that express HPV-biomarkers p16 and MCM7
• 14 days after tamoxifen treatment, mice treated with rapamycin for 3 days exhibit a transient decrease in tumor growth with regrowth after rapamycin is removed
• 14 days after tamoxifen treatment, mice that are treated with image-guided radiotherapy show regression of tumors

craniofacial
• tamoxifen treated mice develop oral tumors; tumors grow faster than in single conditional Kras mutants
• oral tumors of tamoxifen treated mice are papillomas that express HPV-biomarkers p16 and MCM7
• 14 days after tamoxifen treatment, mice treated with rapamycin for 3 days exhibit a transient decrease in tumor growth with regrowth after rapamycin is removed
• 14 days after tamoxifen treatment, mice that are treated with image-guided radiotherapy show regression of tumors

growth/size/body
• tamoxifen treated mice develop oral tumors; tumors grow faster than in single conditional Kras mutants
• oral tumors of tamoxifen treated mice are papillomas that express HPV-biomarkers p16 and MCM7
• 14 days after tamoxifen treatment, mice treated with rapamycin for 3 days exhibit a transient decrease in tumor growth with regrowth after rapamycin is removed
• 14 days after tamoxifen treatment, mice that are treated with image-guided radiotherapy show regression of tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
oral cavity cancer DOID:8618 J:210533


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory