Phenotypes Associated with This Genotype

Genotype
MGI:5659910

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(CAG-HPV16E6E7,-luc)#Mspi/0; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased oral papilloma incidence ( J:210533 )

• tamoxifen treated mice develop oral tumors; tumors grow faster than in single conditional Kras mutants

• oral tumors of tamoxifen treated mice are papillomas that express HPV-biomarkers p16 and MCM7

• 14 days after tamoxifen treatment, mice treated with rapamycin for 3 days exhibit a transient decrease in tumor growth with regrowth after rapamycin is removed

• 14 days after tamoxifen treatment, mice that are treated with image-guided radiotherapy show regression of tumors

digestive/alimentary system

increased oral papilloma incidence ( J:210533 )

• tamoxifen treated mice develop oral tumors; tumors grow faster than in single conditional Kras mutants

• oral tumors of tamoxifen treated mice are papillomas that express HPV-biomarkers p16 and MCM7

• 14 days after tamoxifen treatment, mice treated with rapamycin for 3 days exhibit a transient decrease in tumor growth with regrowth after rapamycin is removed

• 14 days after tamoxifen treatment, mice that are treated with image-guided radiotherapy show regression of tumors

craniofacial

increased oral papilloma incidence ( J:210533 )

• tamoxifen treated mice develop oral tumors; tumors grow faster than in single conditional Kras mutants

• oral tumors of tamoxifen treated mice are papillomas that express HPV-biomarkers p16 and MCM7

• 14 days after tamoxifen treatment, mice treated with rapamycin for 3 days exhibit a transient decrease in tumor growth with regrowth after rapamycin is removed

• 14 days after tamoxifen treatment, mice that are treated with image-guided radiotherapy show regression of tumors

growth/size/body

increased oral papilloma incidence ( J:210533 )

• tamoxifen treated mice develop oral tumors; tumors grow faster than in single conditional Kras mutants

• oral tumors of tamoxifen treated mice are papillomas that express HPV-biomarkers p16 and MCM7

• 14 days after tamoxifen treatment, mice treated with rapamycin for 3 days exhibit a transient decrease in tumor growth with regrowth after rapamycin is removed

• 14 days after tamoxifen treatment, mice that are treated with image-guided radiotherapy show regression of tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oral cavity cancer		DOID:8618		J:210533