Phenotypes Associated with This Genotype

Genotype
MGI:5660499

• Allelic Composition: Jup^tm1Ruiz/Jup⁺; Tg(Myh6-Jup*)1Ajm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system morphology ( J:192719 )

• mice exhibit similar cardiovascular phenotypes as single Tg(Myh6-Jup*)1Ajm transgenic mice

abnormal heart morphology ( J:192719 )

• increase in fibroadipocytes in the heart

thin interventricular septum ( J:192719 )

decreased heart left ventricle muscle contractility ( J:192719 )

• reduced left ventricular fractional shortening

abnormal heart echocardiography feature ( J:192719 )

• increase in left ventricular end diastolic diameter, left ventricular end systolic diameter, and left ventricular mass

adipose tissue

abnormal fat cell morphology ( J:192719 )

• increase in fibroadipocytes in the heart

muscle

decreased heart left ventricle muscle contractility ( J:192719 )

• reduced left ventricular fractional shortening

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arrhythmogenic right ventricular dysplasia 12		DOID:0110083	OMIM:611528	J:192719