Phenotypes Associated with This Genotype

Genotype
MGI:5660857

• Allelic Composition: Nlgn3^tm2.1Sud/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced learning ( J:214636 )

♂ • mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod

increased vertical activity ( J:214636 )

♂ • mice exhibit greater number of wall jumps

increased locomotor activity ( J:214636 )

♂ • mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes, however no changes in movement velocity or in crossings through the center of the open field are seen

stereotypic behavior ( J:214636 )

♂ • mice show an abnormal bias in the direction of rotation during locomotion

increased stereotypic behavior ( J:214636 )

♂ • mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine

♂ • the time spend performing stereotypic movements is enhanced during spontaneous open-field activity

♂ • mice show increased vigor of stereotypic movements, indicated by greater force variance during periods of low mobility

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:214636