Phenotypes Associated with This Genotype

Genotype
MGI:5661067

• Allelic Composition: Reln^rl/Reln⁺
• Genetic Background: B6C3Fe a/a-Reln^rl/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal ventral striatum morphology ( J:107996 )

• mice show an elevation of dopamine D3 receptor expression in the ventral striatum, particularly in the nucleus accumbens and tuberculum olfactorium

decreased dopaminergic neuron number ( J:107996 )

• mice exhibit a reduction in the number of tyrosine hydroxylase-immunoreactive cell bodies in the ventral tegmental area, but not in the medial substantia nigra, pars compacta, indicating dopamine cell loss in the ventral striatum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:107996