Phenotypes Associated with This Genotype

Genotype
MGI:5661330

• Allelic Composition: Col1a1^{tm4(CAG-FGFR2_iIIIb*K660N)Kkw}/Col1a1⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:214230 )

• 92% of mice develop lung tumors with a latency of 28-32 weeks after intranasal delivery of an adenovirus expressing cre recombinase (Ad-cre)

• mice with lung tumors treated with a pan-FGFR inhibitor, BGJ-398, mice show more than 50% tumor regression

increased lung adenocarcinoma incidence ( J:214230 )

• tumors from Ad-cre treated mice resemble poorly differentiated human grade 3/4 lung adenocarcinoma displaying high pleiotropy and heavily multinucleated tumor cells showing local invasion throughout the lung parenchyma

growth/size/body

weight loss ( J:214230 )

• Ad-cre treated mice that become sick present with weight loss

mortality/aging

premature death ( J:214230 )

• mice show a decrease in overall survival after Ad-cre treatment, beginning to die around 20 weeks after Ad-cre delivery and most dying by 50 weeks after Ad-cre administration

respiratory system

increased lung tumor incidence ( J:214230 )

• 92% of mice develop lung tumors with a latency of 28-32 weeks after intranasal delivery of an adenovirus expressing cre recombinase (Ad-cre)

• mice with lung tumors treated with a pan-FGFR inhibitor, BGJ-398, mice show more than 50% tumor regression

increased lung adenocarcinoma incidence ( J:214230 )

• tumors from Ad-cre treated mice resemble poorly differentiated human grade 3/4 lung adenocarcinoma displaying high pleiotropy and heavily multinucleated tumor cells showing local invasion throughout the lung parenchyma

respiratory distress ( J:214230 )

• Ad-cre treated mice that become sick present with progressive dyspnea and weight loss

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:214230