Phenotypes Associated with This Genotype

Genotype
MGI:5661820

• Allelic Composition: Celsr1^Scy/Celsr1⁺; Scrib^Crc/Scrib⁺
• Genetic Background: C3H.Cg-Scrib^Crc Celsr1^Scy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

craniorachischisis ( J:216413 )

• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)

• however, 39% mutants appear normal

growth/size/body

abnormal abdominal wall morphology ( J:216413 )

• 1 of 18 mutants with craniorachischisis show an abdominal wall defect

nervous system

craniorachischisis ( J:216413 )

• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)

• however, 39% mutants appear normal

vision/eye

abnormal eyelid morphology ( J:216413 )

• some mutants with craniorachischisis show eyelid closure defects

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:216413