Phenotypes Associated with This Genotype

Genotype
MGI:5661919

• Allelic Composition: Tg(SFTPC-KIF5B/RET)1Tkoh/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:215989 )

• mice exhibit pulmonary proliferative lesions that include hyperplasias, adenomas and carcinomas; lung tumors have features of human lung adenocarcinomas harboring this fusion protein

• treatment with vandetanib, a RET tyrosine kinase inhibitor drug, suppresses lung tumorigenesis

increased lung adenoma incidence ( J:215989 )

increased lung adenocarcinoma incidence ( J:215989 )

respiratory system

increased lung tumor incidence ( J:215989 )

• mice exhibit pulmonary proliferative lesions that include hyperplasias, adenomas and carcinomas; lung tumors have features of human lung adenocarcinomas harboring this fusion protein

• treatment with vandetanib, a RET tyrosine kinase inhibitor drug, suppresses lung tumorigenesis

increased lung adenoma incidence ( J:215989 )

increased lung adenocarcinoma incidence ( J:215989 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:215989