Phenotypes Associated with This Genotype

Genotype
MGI:5688288

• Allelic Composition: Apc^M1Tno/Apc⁺
• Genetic Background: either: B6JJcl.B6(D2JJcl)-Apc^M1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:218227 )

• 100% of females but only 10.1% of males develop breast cancers

• breast cancers arise from 2 months of age

increased mammary adenocarcinoma incidence ( J:218227 )

• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

increased skin tumor incidence ( J:218227 )

• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors

• trichogenic tumors in males arise from 9 months of age

increased pilomatricoma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

increased trichoepithelioma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

increased osteosarcoma incidence ( J:218227 )

• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas

increased osteoma incidence ( J:218227 )

• 54.2% of females and 93.3% of males exhibit osteomas

• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas

• osteomas in males arise from 9 months of age

mortality/aging

premature death ( J:218227 )

• females become moribund as early as 9 weeks of age

integument

increased mammary gland tumor incidence ( J:218227 )

• 100% of females but only 10.1% of males develop breast cancers

• breast cancers arise from 2 months of age

increased mammary adenocarcinoma incidence ( J:218227 )

• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

increased skin tumor incidence ( J:218227 )

• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors

• trichogenic tumors in males arise from 9 months of age

increased pilomatricoma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

increased trichoepithelioma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:218227 )

• breast cancers arise from 2 months of age

• 100% of females but only 10.1% of males develop breast cancers

increased mammary adenocarcinoma incidence ( J:218227 )

• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

skeleton

increased osteosarcoma incidence ( J:218227 )

• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas

increased osteoma incidence ( J:218227 )

• 54.2% of females and 93.3% of males exhibit osteomas

• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas

• osteomas in males arise from 9 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:218227