Phenotypes Associated with This Genotype

Genotype
MGI:5688300

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-PTPN11*E76K)#Jiwu/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenoma incidence ( J:212505 )

• atypical adenomatous hyperplasia is seen in mice induced with doxycycline (Dox) for 6 months

• 3 of 12 mice induced with Dox for 6 months develop small lung adenomas

• 13 of 15 mice induced with Dox for 9 months develop lung tumors; tumors at 9 months of Dox induction are larger in size and some progress to adenocarcinoma

• lung tumors regress after Dox withdrawal

increased lung non-small cell carcinoma incidence ( J:212505 )

• lung tumors in Dox treated mice are papillary or mixed subtypes of adenomas and progress to mixed subtypes and solid adenocarcinomas and resemble non-small cell lung cancer

respiratory system

increased lung adenoma incidence ( J:212505 )

• atypical adenomatous hyperplasia is seen in mice induced with doxycycline (Dox) for 6 months

• 3 of 12 mice induced with Dox for 6 months develop small lung adenomas

• 13 of 15 mice induced with Dox for 9 months develop lung tumors; tumors at 9 months of Dox induction are larger in size and some progress to adenocarcinoma

• lung tumors regress after Dox withdrawal

increased lung non-small cell carcinoma incidence ( J:212505 )

• lung tumors in Dox treated mice are papillary or mixed subtypes of adenomas and progress to mixed subtypes and solid adenocarcinomas and resemble non-small cell lung cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:212505