Phenotypes Associated with This Genotype

Genotype
MGI:5688354

• Allelic Composition: Dmd^mdx/Dmd^mdx
• Genetic Background: D2.B10-Dmd^mdx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:160773 )

• Background Sensitivity: increased fat accumulation in comparison to Dmd^mdx mice on the C57BL/10 background

behavior/neurological

decreased aerobic running capacity ( J:160773 )

• Background Sensitivity: mice run shorter distances than wild-type and Dmd^mdx mice on the C57BL/10 background

• mice run 45% (male) and 56% (female) shorter distances than wild-type

• maximum running speed in both males and females is less than in wild-type mice

growth/size/body

decreased body weight ( J:160773 )

• decreased body weight as compared to wild-type

homeostasis/metabolism

decreased aerobic running capacity ( J:160773 )

• Background Sensitivity: mice run shorter distances than wild-type and Dmd^mdx mice on the C57BL/10 background

• mice run 45% (male) and 56% (female) shorter distances than wild-type

• maximum running speed in both males and females is less than in wild-type mice

muscle

decreased quadriceps weight ( J:160773 )

• Background Sensitivity: weight of quadriceps femoris is less than both wild-type and Dmd^mdx mice on the C57BL/10 background

decreased skeletal muscle fiber number ( J:160773 )

• Background Sensitivity: decreased number of total myofibers in comparison to Dmd^mdx mice on the C57BL/10 background

decreased skeletal muscle mass ( J:160773 )

• Background Sensitivity: in comparison to Dmd^mdx mice on the C57BL/10 background

decreased skeletal muscle weight ( J:160773 )

• Background Sensitivity: weights of tibialis anterior and gastrocnemius muscles are less than both wild-type and Dmd^mdx mice on the C57BL/10 background

skeletal muscle fibrosis ( J:160773 )

• Background Sensitivity: increased fibrosis volume in quadriceps femoris as compared to Dmd^mdx mice on the C57BL/10 background

muscle weakness ( J:160773 )

• Background Sensitivity: mice exhibit lower grip strength test scores than wild-type mice and Dmd^mdx mice on the C57BL/10 background

limbs/digits/tail

decreased quadriceps weight ( J:160773 )

• Background Sensitivity: weight of quadriceps femoris is less than both wild-type and Dmd^mdx mice on the C57BL/10 background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:160773