Phenotypes Associated with This Genotype

Genotype
MGI:5688562

• Allelic Composition: Lrp4^mdig-3J/Lrp4^mdig-3J
• Genetic Background: B6.Cg-Lrp4^mdig-3J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:224655 )

• homozygotes have shortened or fused digits on all four feet with some toes being both shortened and fused

fused phalanges ( J:224655 )

brachydactyly ( J:224655 )

skeleton

abnormal tooth morphology ( J:224655 )

• the teeth require trimming when the homozygotes are young, but this need goes away as they mature

fused phalanges ( J:224655 )

abnormal spine curvature ( J:224655 )

reproductive system

reduced fertility ( J:224655 )

• some, but not all, homozygotes fail to breed

craniofacial

abnormal tooth morphology ( J:224655 )

• the teeth require trimming when the homozygotes are young, but this need goes away as they mature

growth/size/body

abnormal tooth morphology ( J:224655 )

• the teeth require trimming when the homozygotes are young, but this need goes away as they mature

decreased body size ( J:224655 )

• homoygotes are slightly smaller than normal littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sclerosteosis 2		DOID:0060757	OMIM:614305	J:224655