Phenotypes Associated with This Genotype

Genotype
MGI:5688878

• Allelic Composition: Itgb3^tm1Hyn/Itgb3^tm1.1Wlbcr; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:224675 )

• 15% of mice die postnatally due to spontaneous bleeding

digestive/alimentary system

gastrointestinal hemorrhage ( J:224675 )

• 85% of 8-13 week old mice exhibit gastrointestinal bleeding

hematopoietic system

enlarged spleen ( J:224675 )

decreased hemoglobin content ( J:224675 )

• decreased hemoglobin levels

decreased platelet aggregation ( J:224675 )

• platelet-rich plasma (PRP) does not undergo ADP-induced platelet aggregation

homeostasis/metabolism

abnormal hemostasis ( J:224675 )

abnormal blood coagulation ( J:224675 )

• clot retraction does not occur in platelet-rich plasma (PRP)

decreased platelet aggregation ( J:224675 )

• platelet-rich plasma (PRP) does not undergo ADP-induced platelet aggregation

increased bleeding time ( J:224675 )

immune system

enlarged spleen ( J:224675 )

cardiovascular system

gastrointestinal hemorrhage ( J:224675 )

• 85% of 8-13 week old mice exhibit gastrointestinal bleeding

intracranial hemorrhage ( J:224675 )

• acute and chronic intracranial bleeding

nervous system

intracranial hemorrhage ( J:224675 )

• acute and chronic intracranial bleeding

growth/size/body

enlarged spleen ( J:224675 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Glanzmann's thrombasthenia		DOID:2219	OMIM:273800	J:224675