Phenotypes Associated with This Genotype

Genotype
MGI:5689556

cn53

• Allelic Composition: Runx3^tm3Yg/Runx3^tm3Yg; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body mass index ( J:224290 )

• 20-50% lower body mass

decreased body size ( J:224290 )

• dwarfism

decreased body weight ( J:224290 )

decreased body height ( J:224290 )

• short stature that persists throughout life

limbs/digits/tail

decreased diameter of femur ( J:224290 )

• 21.7% lower bone thickness of 23 day old femurs

decreased femoral compact bone area ( J:224290 )

• 25% smaller cortical area of 23 day old femurs

skeleton

skeleton phenotype ( J:243559 )

• do not display scoliosis at 3 months of age

decreased diameter of femur ( J:224290 )

• 21.7% lower bone thickness of 23 day old femurs

decreased femoral compact bone area ( J:224290 )

• 25% smaller cortical area of 23 day old femurs

decreased bone mineral content ( J:224290 )

• 27.1% reduction in bone mineral content in 23 day old femurs