Phenotypes Associated with This Genotype

Genotype
MGI:5689835

• Allelic Composition: Reln^rl/Reln⁺
• Genetic Background: B6.Cg-Reln^rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal short-term spatial reference memory ( J:223944 )

• chronic administration of corticosterone to induce high stress hormone levels results in disrupted short-term spatial memory in both males and females as indicated by mice showing no preference for the novel arm of the Y-maze as seen in controls

• however, unstressed mutants show normal spatial memory on the Y-maze

abnormal social investigation ( J:223944 )

♂ • untreated and corticosterone treated (stressed) males spend less time sniffing a novel mouse during phase 2 of the social recognition test when mice can choose between a novel and a familiar mouse, indicating impaired social recognition memory

nervous system

abnormal prepulse inhibition ( J:223944 )

♂ • corticosterone treated males do not exhibit disrupted prepulse inhibition as is seen in wild-type corticosterone treated males, indicating that males are resilient to the effects of stress on prepulse inhibition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:223944