Analysis Tools
digestive/alimentary system
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• about 20-25% of mice develop loose stools and anal mucous discharge by 1 year of age
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• dysregulated epithelial cell growth in areas of inflammation
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• intestinal inflammation is characterized by massive thickening of the mucosa and inflammatory cell infiltrates into the lamina propria
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• crypt length is increased in mice with colitis, with about 3-5 fold more epithelial cells per crypt
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• occasional crypt abscesses extending through the mucosa to the muscular layer are seen in mice with colitis
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• occasional ulcerations extending through the mucosa to the muscular layer are seen in mice with colitis
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• active intestinal inflammation that is primarily restricted to the large intestine
• inflammation spreads along the entire length of the colon
• increase in number of infiltrating CD3+ T cells scattered diffusely throughout the lamina propria; majority of infiltrating T cells are CD4+TCRalphabeta+
• presence of numerous B220+ B cell clusters/follicles within the lamina propria
• Gr1+ cellular infiltrates are prominent throughout the lamina propria of the large intestine
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• mice develop spontaneous colitis with an average age of onset at 20 weeks, although the first signs of colitis can be seen between 8 and 36 weeks of age
• severe inflammation of the large intestine resembles human inflammatory bowel disease, ulcerative colitis
• prophylactic treatment with oral antibiotics prevents spontaneous colitis
• mice with active colitis treated with antibiotics show reversal of active inflammation within 3 weeks of continuous treatment
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endocrine/exocrine glands
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• crypt length is increased in mice with colitis, with about 3-5 fold more epithelial cells per crypt
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• occasional crypt abscesses extending through the mucosa to the muscular layer are seen in mice with colitis
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growth/size/body
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• some mice with colitis develop a wasting-type disease
• however, majority of mice with colitis are maintained for up to 3 months without signs of cachexia
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hematopoietic system
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• lymphocytes from colitic mice have enhanced proliferative reactivity to bacterial Ags
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• mice with active colitis show increased serum antibody titers
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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immune system
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• active intestinal inflammation that is primarily restricted to the large intestine
• inflammation spreads along the entire length of the colon
• increase in number of infiltrating CD3+ T cells scattered diffusely throughout the lamina propria; majority of infiltrating T cells are CD4+TCRalphabeta+
• presence of numerous B220+ B cell clusters/follicles within the lamina propria
• Gr1+ cellular infiltrates are prominent throughout the lamina propria of the large intestine
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• mice develop spontaneous colitis with an average age of onset at 20 weeks, although the first signs of colitis can be seen between 8 and 36 weeks of age
• severe inflammation of the large intestine resembles human inflammatory bowel disease, ulcerative colitis
• prophylactic treatment with oral antibiotics prevents spontaneous colitis
• mice with active colitis treated with antibiotics show reversal of active inflammation within 3 weeks of continuous treatment
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• lymphocytes from colitic mice have enhanced proliferative reactivity to bacterial Ags
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• mice with active colitis show increased serum antibody titers
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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• increased in mutants with colitis but not in mutants without active colitis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| inflammatory bowel disease 13 | DOID:0110893 |
OMIM:612244 |
J:51190 | |
