Analysis Tools
behavior/neurological
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• mice are hyperactive in response to a novel environment when assessed in a Y-maze test, indicating short-lasting locomotor hyperactivity in response to acute mild stress
• maternally deprived mutants are hyperactive in a novel environment condition in a Y-maze test and show intermediate activity between that of wild-type and homozygotes in response to novelty in the open field or to amphetamine
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• mice are hyperactive in response to a novel environment when assessed in a Y-maze test, indicating short-lasting locomotor hyperactivity in response to acute mild stress
• maternally deprived mutants are hyperactive in a novel environment condition in a Y-maze test and show intermediate activity between that of wild-type and homozygotes in response to novelty in the open field or to amphetamine
• however, locomotor activity in an open field in a novel environment condition and after saline injection is normal, mice injected with amphetamine exhibit a similar locomotor reaction as wild-type mice, and spatial working memory in the spontaneous alternation aspect of the Y-maze is normal
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• mice exhibit deficits in conspecific recognition as they do not exhibit different durations of sniffing over the first 3 trials of an intruder mouse and no recovery at the 4th trial after the introduction of a second intruder mouse as is seen in wild-type mice
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nervous system
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• prepulse inhibition of acoustic startle response is slightly impaired, with an intermediate level of response between wild-type and homozygous mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:225083 | |
