Analysis Tools
behavior/neurological
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• mice injected with the indirect dopamine agonist amphetamine exhibit a greater hyperactivity compared to similarly treated wild-type mice
• maternally deprived mutants show greater hyperactivity after injection of amphetamine than wild-type mice
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• mice exhibit enhanced locomotor activity in an open field in a novel environment condition and after saline injection
• mice are hyperactive in response to a novel environment when assessed in a Y-maze test
• maternally deprived mutants are hyperactive in a novel environment condition both in an open field and in a Y-maze test, and after injection of amphetamine
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• mice exhibit enhanced locomotor activity in an open field in a novel environment condition and after saline injection
• mice are hyperactive in response to a novel environment when assessed in a Y-maze test
• maternally deprived mutants are hyperactive in a novel environment condition both in an open field and in a Y-maze test, and after injection of amphetamine
• however, spatial working memory in the spontaneous alternation aspect of the Y-maze is normal
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• mice injected with the indirect dopamine agonist amphetamine exhibit hyperactivity
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• mice exhibit deficits in conspecific recognition as they do not exhibit different durations of sniffing over the first 3 trials of an intruder mouse and no recovery at the 4th trial after the introduction of a second intruder mouse as is seen in wild-type mice
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nervous system
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• mice show impaired prepulse inhibition of acoustic startle response using 24 dB prepulses
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:225083 | |
