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Phenotypes Associated with This Genotype
Genotype
MGI:5695047
hm1
Allelic
Composition		 Mlklm1Btlr/Mlklm1Btlr
Genetic
Background		 C57BL/6J-Mlklm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlklm1Btlr mutation (0 available); any Mlkl mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased inflammatory response ( J:225934 )
• mice exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

cellular
decreased cell death ( J:225934 )
• mice exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory