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Phenotypes Associated with This Genotype
Genotype
MGI:5695051
ht2
Allelic
Composition		 Nlrc4m1Btlr/Nlrc4+
Genetic
Background		 C57BL/6J-Nlrc4m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4m1Btlr mutation (0 available); any Nlrc4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:225933 )
• mice exhibit impaired peritoneal macrophage inflammatory responses (i.e., decreased secretion of the proinflammatory cytokine interleukin (IL)-1) in response to priming with flagellin compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory