Phenotypes Associated with This Genotype

Genotype
MGI:5695524

• Allelic Composition: Terc^tm1Rdp/Terc^tm1Rdp
• Genetic Background: B6J.Cg-Terc^tm1Rdp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal bone marrow morphology ( J:213181 )

• increase in bone marrow fat content in aged mice

decreased bone volume ( J:213181 )

• 41.7% and 84.9% decrease in femur bone volume at 3 months of age and in aged mice, respectively

abnormal compact bone morphology ( J:213181 )

• 27.1% and 49.3% increase in cortical porosity in young and aged mice, respectively

decreased compact bone area ( J:213181 )

• 4% and 28.2% decrease in cortical bone area in young and aged mice, respectively

decreased compact bone thickness ( J:213181 )

• decrease in cortical thickness in both young and aged mice

decreased bone trabecula number ( J:213181 )

• young femurs show a more rod-like trabecular structure

increased bone trabecular spacing ( J:213181 )

• increase in trabecular separation

decreased trabecular bone thickness ( J:213181 )

osteoporosis ( J:213181 )

• accelerated bone aging characteristic features of human senile osteoporosis

abnormal osteoid morphology ( J:213181 )

• osteoid significantly decreases with age

abnormal skeleton physiology ( J:213181 )

• bone shows mechanical alterations including an increase in structure model index, a decrease in anisotropy and a decrease in the moment of inertia

abnormal bone ossification ( J:213181 )

• mineralized surface, mineral apposition rate, and bone formation rate dramatically decline with age

adipose tissue

abnormal adipose tissue distribution ( J:213181 )

• increase in bone marrow fat content in aged mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoporosis		DOID:11476	OMIM:166710	J:213181