Phenotypes Associated with This Genotype

Genotype
MGI:5695608

• Allelic Composition: Tg(Alb-HRAS*G12V)28Yu/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased liver tumor incidence ( J:107083 , J:238319 )

• mice develop hepatic tumors, with incidence lower in females than males (J:107083)

• mice develop multi-centric spontaneous hepatic tumors consisting of both hepatic adenoma and hepatocellular carcinoma (J:238319)

• the tumor feeding vessels can receive blood from both the hepatic artery and portal vein (J:238319)

increased hepatocellular carcinoma incidence ( J:107083 , J:238319 )

• 14.3% and 88.2% of males at 6-8 months and older than 9 months of age exhibit hepatocellular carcinoma (J:107083)

• 28.6% of females older than 9 months of age exhibit hepatocellular carcinoma (J:107083)

increased liver adenoma incidence ( J:107083 , J:238319 )

• 15.4%, 90.5% and 94.1% of males at 2-5 months, 6-8 months, and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)

• 4.5% and 52.4% of females at 6-8 months and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)

liver/biliary system

increased liver tumor incidence ( J:107083 , J:238319 )

• mice develop hepatic tumors, with incidence lower in females than males (J:107083)

• mice develop multi-centric spontaneous hepatic tumors consisting of both hepatic adenoma and hepatocellular carcinoma (J:238319)

• the tumor feeding vessels can receive blood from both the hepatic artery and portal vein (J:238319)

increased hepatocellular carcinoma incidence ( J:107083 , J:238319 )

• 14.3% and 88.2% of males at 6-8 months and older than 9 months of age exhibit hepatocellular carcinoma (J:107083)

• 28.6% of females older than 9 months of age exhibit hepatocellular carcinoma (J:107083)

increased liver adenoma incidence ( J:107083 , J:238319 )

• 15.4%, 90.5% and 94.1% of males at 2-5 months, 6-8 months, and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)

• 4.5% and 52.4% of females at 6-8 months and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)

abnormal hepatocyte physiology ( J:107083 )

• hepatocytes exhibit cell cycle arrest at the G0/G1 state

increased hepatocyte apoptosis ( J:107083 )

• the percentage of apoptosis is higher for female hepatocytes than for male hepatocytes

cellular

increased hepatocyte apoptosis ( J:107083 )

• the percentage of apoptosis is higher for female hepatocytes than for male hepatocytes

oxidative stress ( J:107083 )

• ROS production is elevated in both male and female hepatocytes, although the increase is higher in males than females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:107083 , J:238319