Phenotypes Associated with This Genotype

Genotype
MGI:5695752

• Allelic Composition: Hap1^tm2Xjl/Hap1^tm2Xjl; Tg(Camk2a-cre)159Kln/0
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased coping response ( J:224698 )

• 2 month old mice show increased immobility in the forced swim test and in the tail suspension test

• mice treated with imipramine, a tricyclic antidepressant, show increased mobility in the forced swim test and the tail suspension test

anhedonia ( J:224698 )

• mice exhibit lower preference to 1% sucrose solution than controls, indicating anhedonia

abnormal motor coordination/balance ( J:224698 )

• mice perform better on the rotarod most likely due to smaller body size

cellular

abnormal neuron proliferation ( J:224698 )

• a decrease in proliferating cells is seen in the hippocampal dentate gyrus, indicating a decrease in postnatal neurogenesis

growth/size/body

decreased body weight ( J:224698 )

• mild decrease in body weight during postnatal life, however by 4 months of age, weight is similar to controls

nervous system

abnormal neuron proliferation ( J:224698 )

• a decrease in proliferating cells is seen in the hippocampal dentate gyrus, indicating a decrease in postnatal neurogenesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melancholic depression		DOID:1595	OMIM:608516	J:224698