Phenotypes Associated with This Genotype

Genotype
MGI:5697200

• Allelic Composition: Tg(ATXN2*72Q)#Plt/0
• Genetic Background: FVB/N-Tg(ATXN2*72Q)#Plt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:224692 )

• performance on the accelerating rotarod becomes worse starting at 16 weeks of age and mice perform poorly with age

growth/size/body

decreased body size ( J:224692 )

• smaller body size beginning at 8 weeks of age

decreased body weight ( J:224692 )

• mice weigh about 30% less than wild-type mice by 24 week of age

nervous system

abnormal Purkinje cell morphology ( J:224692 )

• Purkinje cell morphological changes at 24 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
spinocerebellar ataxia type 2		DOID:0050955	OMIM:183090	J:224692