Phenotypes Associated with This Genotype

Genotype
MGI:5697288

• Allelic Composition: Grhl3^tm1Bogi/Grhl3^tm1Bogi
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal palate development ( J:226218 )

• E15.5 fetuses have bilateral oral epithelial adhesions between the palatal shelves and the lingual, mandibular, and maxillary surfaces

cleft palate ( J:226218 )

• 1 of 6 fetuses exhibit cleft palate at E15.5

digestive/alimentary system

abnormal palate development ( J:226218 )

• E15.5 fetuses have bilateral oral epithelial adhesions between the palatal shelves and the lingual, mandibular, and maxillary surfaces

cleft palate ( J:226218 )

• 1 of 6 fetuses exhibit cleft palate at E15.5

embryo

abnormal periderm development ( J:226218 )

• expression of Krt6 and activated Notch 1, markers for the periderm, are reduced in the epithelium superficial to the tooth germs, indicating impaired development of the oral periderm

growth/size/body

abnormal palate development ( J:226218 )

• E15.5 fetuses have bilateral oral epithelial adhesions between the palatal shelves and the lingual, mandibular, and maxillary surfaces

cleft palate ( J:226218 )

• 1 of 6 fetuses exhibit cleft palate at E15.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Van der Woude syndrome		DOID:0060239	OMIM:119300 OMIM:606713	J:226218