Phenotypes Associated with This Genotype

Genotype
MGI:5697335

hm4

• Allelic Composition: Lrp2^tm1Her/Lrp2^tm1Her
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal selenium level ( J:211934 , J:211934 )

• on a normal selenium diet kidney selenium levels are around 62% of control levels even though whole body levels are normal (J:211934)

♀ • female mice on a low selenium diet have reduced whole body selenium levels after 12 weeks on the diet, particularly in the kidney (J:211934)

increased urine selenium level ( J:211934 )

• seleno proteins found in the urine, unlike controls

• selenium primarily on N-terminal Sepp1 fragments

decreased glutathione peroxidase activity ( J:211934 )

• plasma activity about 32% of control activity on a normal selenium diet

growth/size/body

growth/size/body region phenotype ( J:211934 )

N • normal body weight

behavior/neurological

behavior/neurological phenotype ( J:211934 )

N • normal neurological phenotypes but not tested thoroughly

renal/urinary system

increased urine selenium level ( J:211934 )

• seleno proteins found in the urine, unlike controls

• selenium primarily on N-terminal Sepp1 fragments