Phenotypes Associated with This Genotype

Genotype
MGI:5697531

• Allelic Composition: Auts2^tm1.1Dare/Auts2^tm1.1Dare; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased food intake ( J:217675 )

• knockouts showed a significantly smaller milk band at P1

impaired righting response ( J:217675 )

• knockout mice show impairment in righting reflex relative to wild type from P3-P9, whereas heterozygotes are not impaired

positive geotaxis ( J:217675 )

• knockout mice took significantly longer to orient their nose to an upward position (turn 180o and face upwards on a slanted platform)

decreased vocalization ( J:217675 )

• knockout mice show significantly less ultrasonic vocalizations (USVs) than wild type following maternal separation across the majority of developmental time points measured

growth/size/body

decreased body length ( J:217675 )

• a striking visual and quantitative reduction in the body length of the knockout mice is sen relative to control littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant intellectual developmental disorder		DOID:0060307	OMIM:PS156200	J:217675