Phenotypes Associated with This Genotype

Genotype
MGI:5698146

• Allelic Composition: Bgn^tm1Mfy/Y; Fmod^tm1Aol/Fmod^tm1Aol
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

accelerated temporomandibular joint osteoarthritis ( J:112779 , J:117908 )

♂ • mice develop first signs of temporomandibular joint osteoarthritis at 6 months of age and show loss of collagen type II expression at its restricted location and expression in the superficial layer of the condylar cartilage (J:112779)

♂ • mice develop accelerated temporomandibular joint osteoarthritis from 6 months of age, showing small vertical clefts in the condylar cartilage and partial disruption of the disk, and loss of regular columnar organization of chondrocytes (J:117908)

♂ • by 18 months of age, extensive articular cartilage erosion is seen resulting in a decrease in cartilage thickness (J:117908)

cellular

increased apoptosis ( J:112779 )

♂ • 2-fold increase in the percentage of apoptotic cells in the mandibular condylar cartilage at 3 months of age

decreased chondrocyte proliferation ( J:117908 )

♂ • PCNA staining is stronger in 3 month old temporomandibular joint fibrocartilage, indicating decreased chondrocyte proliferation

skeleton

decreased chondrocyte proliferation ( J:117908 )

♂ • PCNA staining is stronger in 3 month old temporomandibular joint fibrocartilage, indicating decreased chondrocyte proliferation

abnormal mandible morphology ( J:112779 )

♂ • 2-fold increase in the percentage of apoptotic cells in the mandibular condylar cartilage at 3 months of age

accelerated temporomandibular joint osteoarthritis ( J:112779 , J:117908 )

♂ • mice develop first signs of temporomandibular joint osteoarthritis at 6 months of age and show loss of collagen type II expression at its restricted location and expression in the superficial layer of the condylar cartilage (J:112779)

♂ • mice develop accelerated temporomandibular joint osteoarthritis from 6 months of age, showing small vertical clefts in the condylar cartilage and partial disruption of the disk, and loss of regular columnar organization of chondrocytes (J:117908)

♂ • by 18 months of age, extensive articular cartilage erosion is seen resulting in a decrease in cartilage thickness (J:117908)

osteophytes ( J:117908 )

♂ • osteophytes start to form on the mandibular condyle and the glenoid fossa of the temporal bone from 6 months of age and are well developed by 18 months

abnormal articular cartilage morphology ( J:117908 )

♂ • extensive articular cartilage destruction by 18 months of age resulting in a decrease in cartilage thickness

craniofacial

abnormal mandible morphology ( J:112779 )

♂ • 2-fold increase in the percentage of apoptotic cells in the mandibular condylar cartilage at 3 months of age

accelerated temporomandibular joint osteoarthritis ( J:112779 , J:117908 )

♂ • mice develop first signs of temporomandibular joint osteoarthritis at 6 months of age and show loss of collagen type II expression at its restricted location and expression in the superficial layer of the condylar cartilage (J:112779)

♂ • mice develop accelerated temporomandibular joint osteoarthritis from 6 months of age, showing small vertical clefts in the condylar cartilage and partial disruption of the disk, and loss of regular columnar organization of chondrocytes (J:117908)

♂ • by 18 months of age, extensive articular cartilage erosion is seen resulting in a decrease in cartilage thickness (J:117908)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:112779 , J:117908