Phenotypes Associated with This Genotype

Genotype
MGI:5698359

• Allelic Composition: Tg(MMTV-DMTF1_i2)7Kai/0
• Genetic Background: FVB/NJ-Tg(MMTV-DMTF1_i2)7Kai

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence in breeding females ( J:220608 )

♀ • 42% of parous females develop mammary tumors with a mean latency of 16 months

♀ • multiparous females develop mammary tumors earlier than non-parous females with a mean latency of 460 vs. 545 days

♀ • tumor lesions are highly infiltrated with immune cells and show evidence of keratinization and squamous differentiation; immune infiltrates are mostly T lymphocytes

integument

increased mammary gland tumor incidence in breeding females ( J:220608 )

♀ • 42% of parous females develop mammary tumors with a mean latency of 16 months

♀ • multiparous females develop mammary tumors earlier than non-parous females with a mean latency of 460 vs. 545 days

♀ • tumor lesions are highly infiltrated with immune cells and show evidence of keratinization and squamous differentiation; immune infiltrates are mostly T lymphocytes

mammary gland hyperplasia ( J:220608 )

♀ • mammary glands from 18 month old mice show extensive hyperplasia with multifocal tumor lesions

endocrine/exocrine glands

increased mammary gland tumor incidence in breeding females ( J:220608 )

♀ • 42% of parous females develop mammary tumors with a mean latency of 16 months

♀ • multiparous females develop mammary tumors earlier than non-parous females with a mean latency of 460 vs. 545 days

♀ • tumor lesions are highly infiltrated with immune cells and show evidence of keratinization and squamous differentiation; immune infiltrates are mostly T lymphocytes

mammary gland hyperplasia ( J:220608 )

♀ • mammary glands from 18 month old mice show extensive hyperplasia with multifocal tumor lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:220608