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Phenotypes Associated with This Genotype
Genotype
MGI:5698880
cn7
Allelic
Composition		 Ikzf1tm3Kge/Ikzf1tm3Kge
Tg(CD19-cre/ERT2)1Cgn/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm3Kge mutation (0 available); any Ikzf1 mutation (30 available)
Tg(CD19-cre/ERT2)1Cgn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell apoptosis ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cell apoptosis increases
decreased pre-B cell number ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cells rapidly decline in number
absent pre-B cells ( J:209927 )
• circulating pre-B cells are not found

cellular
abnormal B cell apoptosis ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cell apoptosis increases

immune system
abnormal B cell apoptosis ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cell apoptosis increases
decreased pre-B cell number ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cells rapidly decline in number
absent pre-B cells ( J:209927 )
• circulating pre-B cells are not found

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory