Phenotypes Associated with This Genotype

Genotype
MGI:5702414

• Allelic Composition: Apc^tm2.1Cip/Apc⁺; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:227287 )

• tamoxifen treated mice develop intestinal adenomas after the sporadic loss of the remaining Apc allele

increased colon adenoma incidence ( J:227287 )

• tamoxifen treated mice develop colon adenomas after the sporadic loss of the remaining Apc allele

homeostasis/metabolism

abnormal autophagy ( J:227287 )

• tamoxifen-treated mice show activation of autophagy in tumoral cells

mortality/aging

decreased tumor-free survival time ( J:227287 )

• tamoxifen treated mice show signs of illness and have to be euthanized at 135 days due to large tumor burden

growth/size/body

cachexia ( J:227287 )

• tamoxifen treated mice show loss of body weight, pale feet and hunching

digestive/alimentary system

rectal prolapse ( J:227287 )

• tumors of tamoxifen treated mice in the distal colon and rectum are associated with frequent rectal prolapse

increased intestinal adenoma incidence ( J:227287 )

• tamoxifen treated mice develop intestinal adenomas after the sporadic loss of the remaining Apc allele

increased colon adenoma incidence ( J:227287 )

• tamoxifen treated mice develop colon adenomas after the sporadic loss of the remaining Apc allele

intestine polyps ( J:227287 )

• in tamoxifen treated mice

• prolonged antibiotic administration of tamoxifen treated mice does not affect severity of polyposis

• metaformin treatment impairs the growth of polyps in tamoxifen-treated mice but does not affect adenoma cell proliferation

abnormal gut flora balance ( J:227287 )

• tamoxifen treated mice show a difference in the overall composition of both fecal and ileal microbiota compared to double conditional mice heterozygous for Apc and homozygous for Atg7, with mice showing high levels of Gram- bacteria mostly from Helicobacter in the feces

• ileal mucosa of tamoxifen treated mice has a lower bacterial diversity than in double conditional mice heterozygous for Apc and homozygous for Atg7

• the ratio of Gram- to Gram+ bacteria is lower in tamoxifen treated mice than in double conditional mice heterozygous for Apc and homozygous for Atg7

cellular

abnormal autophagy ( J:227287 )

• tamoxifen-treated mice show activation of autophagy in tumoral cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:227287