Analysis Tools
behavior/neurological
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• mice exhibit impaired contextual fear memory, spending less time freezing in a context in which they received 2 tone-shock pairs
• however, mice show normal cued fear memory
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• in the Morris water maze, mice show mildly impaired spatial learning and memory, showing fewer platform crossings during the training phase and on day 4 of the probe trial, but not on day 7
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• mice exhibit anxiety-like behavior in the elevated plus maze, making fewer open arm entries and having a lower ratio of open arm entries to total arm entries
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• in the novel object recognition task, mice do not exhibit a preference for the novel object over a familiar object as is seen in wild-type mice
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• mice are hyperactive in the open field
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• mice display stereotypic behavior in the marble burying task, burying more marbles and at a faster rate
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• mice show deficits in social interaction, with mice showing no preference for the stranger mouse versus an inanimate object as seen in wild-type mice
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nervous system
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• mice exhibit higher levels of protein synthesis in the brain than wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:227667 | ||
