Phenotypes Associated with This Genotype

Genotype
MGI:5705252

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-EGFR*T790M)8Paow/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenocarcinoma incidence ( J:128700 )

• most mice develop lung lesions only after long-term (28-32 weeks) administration of doxycycline (dox)

• lung tumors of dox treated mice are invasive lung adenocarcinomas

• regression of tumors is seen after removal of the inducer dox

• lung tumors of dox treated mice are resistant to treatment with erlotinib

respiratory system

increased lung adenocarcinoma incidence ( J:128700 )

• most mice develop lung lesions only after long-term (28-32 weeks) administration of doxycycline (dox)

• lung tumors of dox treated mice are invasive lung adenocarcinomas

• regression of tumors is seen after removal of the inducer dox

• lung tumors of dox treated mice are resistant to treatment with erlotinib

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:128700