Phenotypes Associated with This Genotype

Genotype
MGI:5705253

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-EGFR*T790M*L858R)51Paow/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

increased lung adenocarcinoma incidence ( J:128700 )

• mice on a dox diet for 17.5 weeks of age develop a large lung tumor burden; these are heterogeneous adenocarcinomas involving the solid, bronchioalveolar, and papillary subtypes

• tumors of dox treated mice are negative for CC26, a Clara cell protein, and positive for surfactant protein-C, a type II pneumocyte marker, indicating a type II cell-like phenotype

• regression of tumors is seen as early as one week after removal of the inducer dox, however microscopic islands of tumor cells can still be seen even after mice are off dox for 4 weeks

• lung tumors of dox treated mice are resistant to treatment with erlotinib

• tumor bearing mice treated with the geldanamycin analogue, 17-AAG, which inhibits Hsp90, show tumor necrosis although viable tumor nodules remain

• however, mice maintained without dox exhibit normal lung morphology

tachypnea ( J:128700 )

• mice on a doxycycline (dox)-containing diet for 17.5 weeks become tachypneic

neoplasm

increased lung adenocarcinoma incidence ( J:128700 )

• mice on a dox diet for 17.5 weeks of age develop a large lung tumor burden; these are heterogeneous adenocarcinomas involving the solid, bronchioalveolar, and papillary subtypes

• tumors of dox treated mice are negative for CC26, a Clara cell protein, and positive for surfactant protein-C, a type II pneumocyte marker, indicating a type II cell-like phenotype

• regression of tumors is seen as early as one week after removal of the inducer dox, however microscopic islands of tumor cells can still be seen even after mice are off dox for 4 weeks

• lung tumors of dox treated mice are resistant to treatment with erlotinib

• tumor bearing mice treated with the geldanamycin analogue, 17-AAG, which inhibits Hsp90, show tumor necrosis although viable tumor nodules remain

• however, mice maintained without dox exhibit normal lung morphology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:128700