Phenotypes Associated with This Genotype

Genotype
MGI:5705321

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:184935 )

♂ • mice develop invasive carcinoma in both the dorsolateral and anterior lobes of the prostate as early as 4 weeks with poorly differentiated carcinoma by 10 weeks

♂ • marker analysis indicates that prostatic epithelial cells undergo epithelial-to-mesenchymal transition and that tumors exhibit a human metastatic prostate cancer signature

increased metastatic potential ( J:184935 )

♂ • mice develop macrometastatic lesions in the lung and liver with 100% penetrance

mortality/aging

premature death ( J:184935 )

♂ • early lethality, with mice dying between around 10 and 30 weeks of age

endocrine/exocrine glands

abnormal prostate gland morphology ( J:184935 )

♂ • prostates show an expansion of the leukemia stem cell (LSC)^high subpopulation of stem/progenitor cells

♂ • both the LSC^high (basal cell population) and LSC^low (luminal cell population) subpopulations show enhanced sphere-forming in vitro

increased prostate gland adenocarcinoma incidence ( J:184935 )

♂ • mice develop invasive carcinoma in both the dorsolateral and anterior lobes of the prostate as early as 4 weeks with poorly differentiated carcinoma by 10 weeks

♂ • marker analysis indicates that prostatic epithelial cells undergo epithelial-to-mesenchymal transition and that tumors exhibit a human metastatic prostate cancer signature

reproductive system

abnormal prostate gland morphology ( J:184935 )

♂ • prostates show an expansion of the leukemia stem cell (LSC)^high subpopulation of stem/progenitor cells

♂ • both the LSC^high (basal cell population) and LSC^low (luminal cell population) subpopulations show enhanced sphere-forming in vitro

increased prostate gland adenocarcinoma incidence ( J:184935 )

♂ • mice develop invasive carcinoma in both the dorsolateral and anterior lobes of the prostate as early as 4 weeks with poorly differentiated carcinoma by 10 weeks

♂ • marker analysis indicates that prostatic epithelial cells undergo epithelial-to-mesenchymal transition and that tumors exhibit a human metastatic prostate cancer signature

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:184935