Phenotypes Associated with This Genotype

Genotype
MGI:5705328

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Pten^tm1Hwu/Pten⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:184935 )

♂ • lethality around 40 weeks of age

neoplasm

increased prostate gland adenocarcinoma incidence ( J:184935 )

♂ • mice develop focal neoplastic expansions in the prostate by 10 weeks and invasive carcinoma by 20 weeks

increased metastatic potential ( J:184935 )

♂ • mice develop macrometastatic lesions in the lung and liver with 100% penetrance

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:184935 )

♂ • mice develop focal neoplastic expansions in the prostate by 10 weeks and invasive carcinoma by 20 weeks

reproductive system

increased prostate gland adenocarcinoma incidence ( J:184935 )

♂ • mice develop focal neoplastic expansions in the prostate by 10 weeks and invasive carcinoma by 20 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:184935