Phenotypes Associated with This Genotype

Genotype
MGI:5705651

• Allelic Composition: Col1a1^{tm1(tetO-YAP1*)Fcam}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:222916 )

♂ • 4 of 11 mice administered doxycycline at 3 months of age develop prostate tumors with age

♂ • tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors

increased prostate gland adenocarcinoma incidence ( J:222916 )

♂

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:222916 )

♂ • 4 of 11 mice administered doxycycline at 3 months of age develop prostate tumors with age

♂ • tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors

increased prostate gland adenocarcinoma incidence ( J:222916 )

♂

reproductive system

increased prostate gland tumor incidence ( J:222916 )

♂ • 4 of 11 mice administered doxycycline at 3 months of age develop prostate tumors with age

♂ • tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors

increased prostate gland adenocarcinoma incidence ( J:222916 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:222916