Phenotypes Associated with This Genotype

Genotype
MGI:5706939

• Allelic Composition: Tg(IRS1)1Mhep/0; Tg(SERPINA1-HBVX)1655Jtsb/0
• Genetic Background: involves: C3H * C57BL/6 * FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

hepatic steatosis ( J:227278 )

• 9 month old males exhibit substantial dysplastic, steatosis and lobular architectural changes in the liver

• 9 month old females exhibit only mild steatosis

increased hepatocellular carcinoma incidence ( J:227278 )

♂ • males, but not females, develop hepatocellular carcinoma starting at 15-18 months of age

♂ • tumors vary in appearance, size and location, from multiple tiny nodules covering the entire liver to a single large mass

neoplasm

increased hepatocellular carcinoma incidence ( J:227278 )

♂ • males, but not females, develop hepatocellular carcinoma starting at 15-18 months of age

♂ • tumors vary in appearance, size and location, from multiple tiny nodules covering the entire liver to a single large mass

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:227278