Phenotypes Associated with This Genotype

Genotype
MGI:5708536

• Allelic Composition: Enam^tm1.1Jcch/Enam⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal tooth morphology ( J:223123 )

• some irregularity of the ameloblast cell layers, specifically homogeneity and continuity, among molars

abnormal lower incisor morphology ( J:223123 )

• mandibular incisors show disturbed ameloblasts resulting in cyst formation within the enamel organ beginning in late secretory stage

abnormal enamel rod pattern ( J:223123 )

• organized rods are present in incisors but they are spaced further apart

reduced enamel thickness ( J:223123 )

skeleton

abnormal tooth morphology ( J:223123 )

• some irregularity of the ameloblast cell layers, specifically homogeneity and continuity, among molars

abnormal lower incisor morphology ( J:223123 )

• mandibular incisors show disturbed ameloblasts resulting in cyst formation within the enamel organ beginning in late secretory stage

abnormal enamel rod pattern ( J:223123 )

• organized rods are present in incisors but they are spaced further apart

reduced enamel thickness ( J:223123 )

growth/size/body

abnormal tooth morphology ( J:223123 )

• some irregularity of the ameloblast cell layers, specifically homogeneity and continuity, among molars

abnormal lower incisor morphology ( J:223123 )

• mandibular incisors show disturbed ameloblasts resulting in cyst formation within the enamel organ beginning in late secretory stage

abnormal enamel rod pattern ( J:223123 )

• organized rods are present in incisors but they are spaced further apart

reduced enamel thickness ( J:223123 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amelogenesis imperfecta type 1B		DOID:0110052	OMIM:104500	J:223123