Phenotypes Associated with This Genotype

Genotype
MGI:5749568

cn1

• Allelic Composition: Mecp2^tm1Bird/Y; Sst^{tm2.1(cre)Zjh}/Sst⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:228740 )

♂ • 50% mortality by 29-35 weeks of age

behavior/neurological

increased stereotypic behavior ( J:228740 )

♂ • mice exhibit repetitive nose-poking behavior in the hole board test

♂ • however, mice do not exhibit motor deficits or alternations in acoustic startle response, partition, or cued memory tests, or differences in anxiety, pre-pulse inhibition, locomotor activity or long-term potentiation

seizures ( J:228740 )

♂ • 50% of mice develop spontaneous epileptic seizures starting at 12 weeks

tonic-clonic seizures ( J:228740 )

♂ • mice show generalized tonic clonic seizures during routine handling

nervous system

seizures ( J:228740 )

♂ • 50% of mice develop spontaneous epileptic seizures starting at 12 weeks

tonic-clonic seizures ( J:228740 )

♂ • mice show generalized tonic clonic seizures during routine handling