Phenotypes Associated with This Genotype

Genotype
MGI:5749790

• Allelic Composition: Tg(Camk2a-MAPT)601Ymot/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:172762 )

♀ • 16 month old mice do worse in memory retention (probe) test of the Morris water maze

♀ • however, mice show no differences in motor function or activity

impaired spatial learning ( J:172762 )

♀ • 16 month old mice take longer to learn the task in the acquisition test of the Morris water maze indicating impaired place learning

abnormal spatial working memory ( J:172762 )

♀ • 16 month old mice show decreased spontaneous alternation in the Y-maze indicating impaired working memory

decreased anxiety-related response ( J:172762 )

♀ • 16 month old mice spend more time in the open arms of the elevated plus maze test than controls, indicating impaired anxiety

cellular

decreased cellular glucose uptake ( J:172762 )

♀ • living old mice show decreased glucose metabolism in the nucleus accumbens

nervous system

abnormal nucleus accumbens morphology ( J:172762 )

♀ • 16 month old mice show loss of synapses and dendritic spines in the nucleus accumbens

abnormal axon morphology ( J:172762 )

♀ • mice exhibit axonal dilatations primarily in cortical layers V and VI of the prefrontal cortex with aging, as well as in the sensorimotor cortex and the orbitofrontal cortex

♀ • however, mice do not exhibit formation of tau aggregates or neurofibrillary tangles and show no signs of neuronal loss, astrogliosis, or microglial proliferation

abnormal dendritic spine morphology ( J:172762 )

♀ • 16 month old mice show loss of dendritic spines in the nucleus accumbens

abnormal synapse morphology ( J:172762 )

♀ • 16 month old mice show loss of synapses in the nucleus accumbens

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
frontotemporal dementia		DOID:9255	OMIM:600274	J:172762