Analysis Tools
behavior/neurological
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• mice show increased footslips in the parallel rod walking task and impaired ability to learn the accelerating rotating rod walking task at 17 weeks of age
• however, no difference is seen in the motor coordination task of dowel hang time and mice exhibit normal behaviors in the elevated plus maze
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• two mice show tonic-clonic seizures followed by death after handling
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respiratory system
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• 8 month old mice exhibit increased breathing rate when exposed to a hypoxic gas challenge
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cardiovascular system
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• increase in heart weight by 8 months
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• 8 month old mice show increased corrected QT interval time
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growth/size/body
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• increase in heart weight by 8 months
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• mice become overweight by 10 weeks of age
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• increase in liver weight by 8 months of age
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liver/biliary system
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• increase in liver weight by 8 months of age
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mortality/aging
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• median survival of 224 days
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nervous system
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• two mice show tonic-clonic seizures followed by death after handling
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:220859 | |
