Phenotypes Associated with This Genotype

Genotype
MGI:5752193

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 11.3 months

♀ • expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

increased spindle cell carcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer

increased myoepithelioma incidence ( J:224955 )

♀ • 17% of mammary tumors are adenomyoepithelioma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 11.3 months

♀ • expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

integument

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 11.3 months

♀ • expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:224955