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Phenotypes Associated with This Genotype
Genotype
MGI:5752196
Allelic
Composition		 Ptentm2Mak/Ptentm2Mak
Trp53tm1Brn/Trp53tm1Brn
Tg(Wap-cre)11738Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2Mak mutation (4 available); any Pten mutation (88 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:224955 )
• females develop mammary tumors with a latency of 9.8 months
• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features
increased mammary adenocarcinoma incidence ( J:224955 )
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas
increased spindle cell carcinoma incidence ( J:224955 )
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer
increased myoepithelioma incidence ( J:224955 )
• 11% of mammary tumors are adenomyoepithelioma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:224955 )
• females develop mammary tumors with a latency of 9.8 months
• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features
increased mammary adenocarcinoma incidence ( J:224955 )
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

integument
increased mammary gland tumor incidence ( J:224955 )
• females develop mammary tumors with a latency of 9.8 months
• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features
increased mammary adenocarcinoma incidence ( J:224955 )
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:224955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory