Phenotypes Associated with This Genotype

Genotype
MGI:5752237

• Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh; Kras^tm4Tyj/Kras⁺; Tg(Tyr-cre/ERT2)13Bos/0
• Genetic Background: B6J.Cg-Tg(Tyr-cre/ERT2)13Bos Cdkn2a^tm2.1Nesh Kras^tm4Tyj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

hyperpigmentation ( J:220627 )

• mice treated with 4-hydroxytamoxifen (4-OHT) neonatally exhibit the presence of nevi and hyperpigmented regions on the paws and tails

integument

increased cutaneous melanoma incidence ( J:220627 )

• mice treated with 4-OHT neonatally develop melanoma with 76% penetrance and a median latency of 36.3 weeks

• melanomas contain both spindle-cell and desmoplastic cell types with no overt signs of macrometastatic spread

neoplasm

increased cutaneous melanoma incidence ( J:220627 )

• mice treated with 4-OHT neonatally develop melanoma with 76% penetrance and a median latency of 36.3 weeks

• melanomas contain both spindle-cell and desmoplastic cell types with no overt signs of macrometastatic spread

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:220627