Phenotypes Associated with This Genotype

Genotype
MGI:5752313

• Allelic Composition: Tbr1^tm1Jlr/Tbr1⁺
• Genetic Background: B6.129X1-Tbr1^tm1Jlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal conditioned taste aversion behavior ( J:208050 )

• in the conditioned taste aversion after training with LiCl injection, mutants do not recognize sucrose as a hazardous food and drink more sucrose than water

• treatment with D-Cycloserine ameliorates the conditioned taste aversion defect

abnormal cued conditioning behavior ( J:208050 )

• mice exhibit defective auditory fear conditioning, showing a lower freezing response when examined for auditory fear memory

• treatment with D-Cycloserine ameliorates the auditory fear conditioning defect

• however, mice do not exhibit deficits in open-field and elevated plus-maze tests or in novel object recognition or contextual fear conditioning

impaired social transmission of food preference ( J:208050 )

• mice do not show a preference for the cued food in an assay for social transmission of food preference

cognitive inflexibility ( J:208050 )

• in the appetitive-motivated T maze, during reversal learning, mice take a longer amount of time to realize that the reward had been changed to the other am in the T-maze indicating impaired cognitive flexibility

• in the two-choice digging test, mice take more trials to relearn that food had been moved to the bowl filled with cinnamon-flavored sawdust

abnormal social investigation ( J:208050 )

• mice show deficits in sociability in the three-chamber test, but not in preference for social novelty

• in a test of reciprocal social interaction, mice spend less time interacting with unfamiliar mice

• treatment with D-Cycloserine, a partial agonist of NMDA receptors, ameliorates the social interaction defects

decreased vocalization ( J:208050 )

• pups isolated from their mothers produce fewer ultrasonic vocalization emissions

nervous system

abnormal anterior commissure morphology ( J:208050 )

• posterior part of the anterior commissure is missing

abnormal amygdala morphology ( J:208050 )

• mice rarely show long processes extending from amygdalar neurons

• amygdalar neurons grown in culture develop multiple axons and each axon is shorter at 4 days in vitro compared to wild-type neurons

• however, cortical and striatal neuron morphology is normal

abnormal innervation ( J:208050 )

• the inter-amygdalar connections are greatly diminished

• defects in the connection between the ipsilateral central amygdala and basolateral amygdala

abnormal neuron physiology ( J:208050 )

• neuronal activation in the amygdala is impaired

• treatment with D-Cycloserine increases neuronal activity in the amygdala

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:208050