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Phenotypes Associated with This Genotype
Genotype
MGI:5752529
ht2
Allelic
Composition
Pk27053/Pk27053+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pk27053 mutation (1 available); any Pk27053 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• erythrocyte pyruvate kinase activity in heterozygous mutant mice is elevated up to 160% that of wild-type mice.
• liver pyruvate kinase activity is elevated in mice heterozygous for this mutation.
• pyruvate kinase activity in brain, heart, kidney, lung, muscle, and spleen of mutant mice is similar to that observed in these organs from wild-type mice.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory