Phenotypes Associated with This Genotype

Genotype
MGI:5752531

hm1

• Allelic Composition: Pk27053/Pk27053
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased pyruvate kinase activity ( J:82809 )

• liver pyruvate kinase activity is elevated in mice homozygous for this mutation.

• erythrocyte pyruvate kinase activity in homozygous mutant mice is elevated up to 240% that of wild-type mice.

• pyruvate kinase activity in brain, heart, kidney, lung, muscle, and spleen of mutant mice is similar to that observed in these organs from wild-type mice.