Phenotypes Associated with This Genotype

Genotype
MGI:5752786

• Allelic Composition: Disc1^m1H/Disc1^m1H
• Genetic Background: B6N.C(C3H)-Disc1^m1H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:229661 )

N • mice exhibit normal behavior in forced swim and tail suspension tests

N • mice exhibit normal acoustic startle and prepulse inhibition response

impaired passive avoidance behavior ( J:229661 )

♀ • female mice exhibit a deficit in passive avoidance compared with wild-type mice

decreased exploration in new environment ( J:229661 )

♀ • female, but not male, mice exhibit fewer head dips in an elevated plus maze compared with wild-type mice

increased anxiety-related response ( J:229661 )

♀ • female, but not male, mice spend less time in the open arms and more time in the closed arms of an elevated plus maze compared with wild-type mice

increased thigmotaxis ( J:229661 )

♀ • female, but not male, mice spend more time in the outer zone and less time in the center zone of an open field compared with wild-type mice

decreased vertical activity ( J:229661 )

♂ • in male, but not female, mice

increased locomotor activity ( J:229661 )

♀ • hyperlocomotion in a novel open field in female, but not male, mice

abnormal social investigation ( J:229661 )

♀ • female, but not male, mice exhibit reduced investigation of a novel or previously introduced mouse compared with wild-type mice

♀ • however, mice can discriminate between different stranger mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:229661