About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5754385
Allelic
Composition		 Psen1tm2Shn/Psen1tm4.1Shn
Psen2tm1Haa/Psen2tm1Haa
Tg(Camk2a-cre)1Shn/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation (1 available); any Psen1 mutation (48 available)
Psen1tm4.1Shn mutation (0 available); any Psen1 mutation (48 available)
Psen2tm1Haa mutation (0 available); any Psen2 mutation (32 available)
Tg(Camk2a-cre)1Shn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:219929 )
• in the neocortex and hippocampus
abnormal cerebral cortex morphology ( J:219929 )
• 31.5% reduction in cortical volume at 18 months of age
abnormal neocortex morphology ( J:219929 )
• increase in apoptosis in the neocortex
astrocytosis ( J:219929 )
• in the cortex
decreased neuron number ( J:219929 )
• 22.1% reduction in neuron number in the cerebral cortex at 18 months of age
neurodegeneration ( J:219929 )
• mice exhibit age-dependent neurodegeneration throughout the cerebral cortex

hematopoietic system
microgliosis ( J:219929 )
• in the neocortex and hippocampus

immune system
microgliosis ( J:219929 )
• in the neocortex and hippocampus

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:219929

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory