Phenotypes Associated with This Genotype

Genotype
MGI:5754961

cn2

• Allelic Composition: Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud; Tg(Pcp2-cre)2Mpin/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:227671 )

N • no change in density, distribution or size of excitatory climbing-fiber synapses or inhibitory basket/stellate cell synapses

increased excitatory postsynaptic current amplitude ( J:227671 )

• 25% increase in climbing fiber synapse EPSC amplitude

abnormal inhibitory postsynaptic currents ( J:227671 )

• 50% reduction in IPSC amplitude

decreased miniature inhibitory postsynaptic current frequency ( J:227671 )

• 67% decrease in spontaneous mIPSC frequency, but no change in amplitude or kinetics